ImmunoNephelometric Determination of Free Light Chains of Immunoglobulins in Urine for the Detection of Bence Jones Proteins, and Comparison with Immunofixation
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منابع مشابه
Studies of Bence Jones Proteins by Immunonephelometry*t
Plasma cell dyscrasia is a disease caused by a monoclonal population of plasma cells. Most often the workup for this disease is prom pted by the appearance of a paraprotein in serum, but a significant num ber of cases exhibit only a Bence Jones protein. Immunofixation electrophoresis is the most sensitive m ethod presently used for identifying Bence Jones protein uria. This methodology is labo...
متن کاملBence Jones proteinuria in multiple sclerosis.
We report our findings of Bence Jones proteins (monoclonal free light chains of immunoglobulins) in concentrated urines of patients with multiple sclerosis, by using agarose electrophoresis and immunofixation. The lack of such findings in urines from healthy subjects and patients with other neurological disorders should stimulate further investigation.
متن کاملSerum free light chains: an alternative to the urine Bence Jones proteins screening test for monoclonal gammopathies.
BACKGROUND Retrospective analyses have established the role of quantitative serum free light chains (FLCs) in the diagnosis of monoclonal light chain disorders. The aims of this study were to assess (a) whether the addition of serum FLCs to serum protein electrophoresis (SPEP) identified additional patients with monoclonal gammopathies; (b) whether serum FLC measurements could replace urinalysi...
متن کاملSerum Free Light Chains: An Alternative Test to Urine Bence Jones Proteins When Screening for Monoclonal Gammopathies
Background: Retrospective analyses have established the role of quantitative serum free light chains (FLCs) in the diagnosis of monoclonal light chain disorders. The aims of this study were to assess (a) whether the addition of serum FLCs to serum protein electrophoresis (SPEP) identified additional patients with monoclonal gammopathies; (b) whether serum FLC measurements could replace urinalys...
متن کاملBence Jones proteins identified by immunofixation electrophoresis of concentrated urine.
addressed some recently recognized problems in testing concentrated urine for monoclonal free light chains of immunoglobulins, i.e., Bence Jones protein (BJP), by high-resolution elec-trophoresis (lIRE) and immunofix-ation electrophoresis (IFE). When BJP is present in low concentrations, poly-clonal free light chains can interfere with identification of the protein either by causing a dense bac...
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